Clinical Challenges and Complications of IBD

Physicians treating patients with Inflammatory Bowel Disease (IBD) often face challenges due to the disease itself, associated conditions, and systemic effects. Recently, new medications have been introduced that allow for more aggressive and effective treatment of IBD. With these medications come the risks of adverse side effects, and physicians must vigilantly monitor for any complications.

Drs. Miguel D. Regueiro and Jason Swoger have created a unique, user-friendly book that describes how to prevent, recognize, and manage complications encountered in the care of patients with IBD. Clinical Challenges and Complications of IBD aims to provide practical and clinically oriented information to assist physicians with commonly encountered complications of the natural history of IBD, extraintestinal manifestations of IBD, general health and metabolic complications of IBD, and complications arising from both the medical and surgical treatments of IBD.

Formatted to allow for quick access of the information, Clinical Challenges and Complications of IBD is organized into sections that allow physicians to both identify potential pitfalls in treatment, as well as focus on health maintenance and specific challenges, including pregnancy, nutrition, and psychological issues. Clinical pearls will be emphasized and each chapter will provide a bulleted summary, along with suggestions for future reading.

Clinical Challenges and Complications of IBD is an invaluable guide for gastroenterologists, nurse practitioners, physician assistants, and gastroenterology trainees as it is a one-of-a-kind resource for recognizing and dealing with the challenges and complications in patients with IBD.

Dedication
Acknowledgments
About the Editors
Contributing Authors
Preface
Introduction

Section I Complications Related to IBD
Chapter 1 Upper Gastrointestinal Tract Crohn’s Disease
Mark Lazarev, MD and Jemilat O. Badamas, MD
Chapter 2 Internal Fistula, Abscesses, and Strictures: Evaluation With Novel Radiographic Techniques and Clinical Management
Peter D.R. Higgins, MD, PhD, MSc
Chapter 3 Perianal Disease and Perianal Fistulizing Disease in Crohn’s Disease
Leyla J. Ghazi, MD and David A. Schwartz, MD
Chapter 4 Toxic Ulcerative Colitis and Megacolon
Garret Cullen, MD and Adam S. Cheifetz, MD
Chapter 5 Dysplasia and Colorectal Cancer
Fernando Velayos, MD, MPH
Chapter 6 Infections in IBD: Clostridium difficile and Cytomegalovirus
Ashwin N. Ananthakrishnan, MD, MPH

Section II Extraintestinal Manifestations of IBD
Chapter 7 Joint Disease
Kim L. Isaacs, MD, PhD
Chapter 8 Skin and Oral Disease
Lisa M. Grandinetti, MD, FAAD, MMS and Jason M. Swoger, MD, MPH
Chapter 9 Eye Disease
Aaron S. Bancil, BSc (Hons); David G. Walker, BSC (Hons), MBBS, MD (Res), MRCP; and Timothy R. Orchard, MA, MD, DM, FRCP
Chapter 10 Hepatobiliary Disease
Mark E. Gerich, MD and Edward V. Loftus Jr, MD

Section III General Health and Metabolic Complications of IBD
Chapter 11 Women’s Health: Pregnancy, Fertility, and Cervical Cancer
Monika Fischer, MD, MSCR and Sunanda Kane, MD, MSPH
Chapter 12 Nutritional Complications of IBD
Sulieman Abdal Raheem, MD; Omer J. Deen, MD; and Donald F. Kirby, MD, FACP, FACN, FACG, AGAF, CNSC, CPNS
Chapter 13 Vaccination and Immunization Issues
for Patients With IBD
Gil Y. Melmed, MD, MS
Chapter 14 Psychiatric Complications of IBD
David Benhayon, MD, PhD and Eva Szigethy, MD, PhD

Section IV Complications Due to Immunomodulators and Anti-Tumor Necrosis Factors
Chapter 15 Immunomodulators: Azathioprine/6-Mercaptopurine and Methotrexate
Miles P. Sparrow, MBBS, FRACP and David T. Rubin, MD
Chapter 16 Anti-Tumor Necrosis Factor Therapy: Safety and Toxicity
A. Hillary Steinhart, MD, MSc, FRCP(C)

Section V Postoperative Crohn’s Disease and Ulcerative Colitis
Chapter 17 Postoperative Crohn’s Disease Recurrence and Prevention
Miguel D. Regueiro, MD
Chapter 18 Ulcerative Colitis: Pouchitis and Stoma Complications
Udayakumar Navaneethan, MD and Bo Shen, MD

Financial Disclosures
Index

Miguel D. Regueiro, MD, is Professor of Medicine at the University of Pittsburgh School of Medicine, Head of the Clinical Inflammatory Bowel Disease Program, and Co-Director of the Inflammatory Bowel Disease Center at the University of Pittsburgh Medical Center. He is also the Associate Chief for Education and Director of the Gastroenterology, Hepatology, and Nutrition Fellowship Training Program at the University of Pittsburgh. Dr. Regueiro’s primary clinical and research interest is inflammatory bowel disease (IBD), with a focus on Crohn’s disease and ulcerative colitis. Dr. Regueiro has published extensively on the prevention and management of postoperative Crohn’s disease and genotype–phenotype correlations in IBD. He is the principal investigator on several multicenter, international research trials and conducts clinical research that defines the natural course and phenotypes of IBD. Dr. Regueiro has developed a multidisciplinary IBD Center that operates as a state-of-the-art clinic for patients with Crohn’s disease and ulcerative colitis. Dr. Regueiro received his BA at the University of Pennsylvania and earned his medical degree at Hahnemann University. He completed his internal medicine internship and residency and clinical and research fellowship training in gastroenterology at Harvard Medical School’s Beth Israel Hospital. Dr. Regueiro has received several honors, including membership in several professional and scientific societies, including the Alpha Omega Alpha Honor Society, the Joan Komblum Memorial Prize for Excellence in Internal Medicine, the Clinical Investigator Training Award from Harvard/MIT Health Sciences, the Crohn’s Colitis Foundation of America Physician of the Year, the National Research Excellence in Gastroenterology Disease Award, and American Gastroenterology Association and American College of Gastroenterology Fellowships.  

Jason M. Swoger, MD, MPH, is Assistant Professor of Medicine in the Division of Gastroenterology, Hepatology, and Nutrition at the University of Pittsburgh Medical Center. He is Associate Program Director of the Gastroenterology Fellowship Program. Prior to attending medical school, he completed a Master’s of Public Health, with a focus on epidemiology, at the University of Illinois at Chicago. Dr. Swoger received his medical degree from Eastern Virginia Medical School, in Norfolk, VA, where he was a member of the Alpha Omega Alpha Honor Society. He then went on to complete his internal medicine residency training at the Cleveland Clinic Foundation. His fellowship training in gastroenterology was pursued at the Mayo Clinic, in Rochester, MN, where he developed an interest in inflammatory bowel disease, as well as in clinical research. His current research interests include the epidemiology and therapeutics of inflammatory bowel disease, as well as clinical trials. Dr. Swoger is a member of several professional and scientific societies, including the American Gastroenterological Association, the American College of Gastroenterology, and the Crohn’s & Colitis Foundation of America (CCFA), and he is a member of the CCFA Research Alliance. He lives in Pittsburgh with his wife, Lisa.