Biologic Knee Reconstruction: A Surgeon's Guide

Brian Cole, MD; Joshua Harris, MD
ISBN 10:
ISBN 13:
Publication Date:
Item Number:
Product Dimensions:
8.50 x 11.00 x 0.50 inches

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Book Description

Treatment of articular cartilage pathology in the knees of young and active patients is a challenging and controversial issue. Biologic Knee Reconstruction: A Surgeon's Guide is a how-to, step-by-step guide that addresses the evaluation and management of this unique patient population.
Internationally renowned cartilage experts Dr. Brian J. Cole and Dr. Joshua D. Harris, along with their contributors, present information on normal and abnormal history and physical examination. The reader will learn proper decision-making using a patient-centered approach of treatment, increasing the likelihood of a successful outcome. In addition to radiographic assessment of articular cartilage, Biologic Knee Reconstruction discusses the use of biomarkers, defect classification, and patient-reported and surgeon-measured outcomes. Aggressive nonsurgical medical management, including medications, injections, physiotherapy, and rehabilitation, is also presented.
Biologic Knee Reconstruction also discusses the management of concomitant pathologies such as malalignment, meniscal deficiency, and ligamentous instability. Selection of surgical cartilage restorative treatment options is multifactorial, requiring consideration of several patient-, knee-, and defect-specific issues. All contemporary open and arthroscopic cartilage techniques are presented in detail with high resolution figures. A unique feature of Biologic Knee Reconstruction is the presentation of several chapters discussing non-medical issues highly pertinent to the advancement and future of this field: funding of research and cost of new advanced technologies, regulation of advanced cellular, tissue, and genetic technologies, evidence-based medicine and clinical trial design and conduct, and the ethics of allograft tissues and stem cell use.
  • Technique preference cards from the experts performing cartilage surgery
  • Patient education information
  • The most up-to-date descriptions of advanced cartilage techniques
  • Unique chapters not covered in books elsewhere, including:
    • Biomarkers
    • Patient-reported outcomes assessment
    • Newer injection techniques (PRP, stem cells)
    • One- and two-stage open and arthroscopic techniques using chondrocyte- and stem cell based cell therapies
    • Costs and public and private funding of research
    • Barriers to high-quality randomized trials
    • Governmental regulation and availability/accessibility to patients
    • Gene therapy and tissue engineering
    • Ethics of articular cartilage surgery with stem cells, ex-vivo cell manipulation, and juvenile tissue sources
With the most up-to-date content and step-by-step methods for surgical procedures, Biologic Knee Reconstruction: A Surgeon's Guide is the perfect addition to the bookshelf of the orthopedic surgeon, cartilage researcher, sports physical therapist, or athletic trainer who evaluates and manages this unique patient population.

More Information


About the Editors
Contributing Authors 
Foreword by Lars Peterson, MD, PhD 

Section I Introduction 
Chapter 1 Articular Cartilage and Subchondral Bone Anatomy and Physiology
Jason J. Shin, MD; Adam B. Yanke, MD; and Nikhil N. Verma, MD
Chapter 2 Articular Cartilage and Subchondral Bone Pathology 
Brian Chilelli, MD; Gloria Matthews, DVM, PhD; Tom Minas, MD; and Andreas H. Gomoll, MD
Chapter 3 Patient Evaluation: History and Physical Examination 
Michael B. Ellman, MD and Charles A. Bush-Joseph, MD
Chapter 4 Preoperative Articular Cartilage and Subchondral Bone Imaging 
Amit Gupta, MD; Michael C. Forney, MD; and Carl S. Winalski, MD
Chapter 5 Postoperative Articular Cartilage and Subchondral Bone Imaging 
Michael C. Forney, MD; Amit Gupta, MD; and Carl S. Winalski, MD
Chapter 6 Biomarkers in Early and Post-Traumatic Osteoarthritis 
Ariel M. Bodker, MD; Christian Lattermann, MD; and Susan Chubinskaya, PhD
Chapter 7 Chondral and Osteochondral Defect Classification 
Jonathan M. Frank, MD and Bernard R. Bach Jr, MD
Chapter 8 Patient- and Surgeon-Reported Outcomes Assessment 
Brandon Beamer, MD and Frank McCormick, MD

Section II Nonsurgical Treatment 
Chapter 9 Pharmacological Treatments 
Julia Bruene, MD and Kathleen Weber, MD, MS
Chapter 10 Rehabilitation and Physiotherapy 
Brandon Johnson, MD and Bert R. Mandelbaum, MD, DHL (Hon)

Section III Cartilage Palliation Techniques
Chapter 11 Debridement and Chondroplasty for Focal Chondral Defects
Sanjeev Bhatia, MD; Rachel M. Frank, MD; and Brian Forsythe, MD

Section IV Cartilage Repair Techniques 
Chapter 12 Subchondral Bone Treatment
Geoffrey D. Abrams, MD; Joshua D. Harris, MD; and Brian J. Cole, MD, MBA 
Chapter 13 Internal Fixation for Chondral and Osteochondral Lesions 
Ryan J. McNeilan, MD; David C. Flanigan, MD; and Kyle Randall, MD
Chapter 14 Microfracture, Nanofracture, PowerPick, and Abrasion Arthroplasty 
Ethan Kellum, MD, MS and Kai Mithoefer, MD
Chapter 15 Enhanced Marrow-Stimulation Techniques 
Rachel M. Frank, MD; Kai Mithoefer, MD; Sanjeev Bhatia, MD; and Brian J. Cole, MD, MBA

Section V Cartilage Restoration Techniques: Cell-Based Therapies
Chapter 16 Osteochondral Autograft
Adam S. Wilson, MD and Mark D. Miller, MD
Chapter 17 Fresh Osteochondral Allograft 
Joshua D. Harris, MD and Brian J. Cole, MD, MBA
Chapter 18 Autologous Chondrocyte Implantation 
Andreas H. Gomoll, MD
Chapter 19 Other Chondrocyte-Based Cell Therapies 
Giuseppe Filardo, MD, PhD; Luca Andriolo, MD; Elizaveta Kon, MD; and Maurilio Marcacci, MD, Prof
Chapter 20 Stem Cell-Based Cell Therapies 1
Elizaveta Kon, MD; Alice Roffi, BSc; Giuseppe Filardo, MD, PhD; and Maurilio Marcacci, MD, Prof

Section VI Combined Techniques: Biologic Knee Reconstruction 
Chapter 21 Malalignment—Varus—High Tibial Osteotomy 
Francesca de Caro, MD and Annunziato Amendola, MD
Chapter 22 Malalignment—Valgus—Distal Femoral Osteotomy
Gregory A. Sawyer, MD and Robert F. LaPrade, MD, PhD
Chapter 23 Proximal and Distal Patellofemoral Surgery 
Jack Farr, MD and Andreas H. Gomoll, MD
Chapter 24 Meniscal Deficiency: Repair and Transplantation 
Peter N. Chalmers, MD; Robert A. Sershon, MD; and Brian J. Cole, MD, MBA

Section VII The Future of Articular Cartilage Surgery
Chapter 25 Costs and Research Funding: Public and Private Sources 
Geoffrey S. Van Thiel, MD, MBA and Brian J. Cole, MD, MBA
Chapter 26 Governmental Regulation and Availability and Accessibility to Patients 
Jonathan A. Godin, MD, MBA and Richard C. Mather III, MD, MBA
Chapter 27 Barriers to High-Quality Randomized Trials: Noninferiority to Superiority 
Jaskarndip Chahal, MD, MSc, FRCSC and Ken Zaslav, MD
Chapter 28 Gene Therapy and Tissue Engineering 
Laurie R. Goodrich, DVM, PhD, Diplomate ACVS
Chapter 29 Ethics of Articular Cartilage Surgery: Stem Cells, Ex Vivo Manipulation, and Juvenile Sources
H. Davis Adkisson, PhD; Philip R. Streeter, PhD; Kevin F. Bonner, MD; and Joseph Feder, PhD

Financial Disclosures


“This is a wonderful reference on a growing area and that has had an important impact on patient function, especially over the past decade. This guide provides foundational knowledge and well thought out approaches for residents and fellows in training and a thorough reference for orthopedic surgeons in practice who wish to stay current on the state of the art of biological knee reconstruction.”

- Mark R. Hutchinson, MD, University of Illinois at Chicago College of Medicine, Doody’s Review Service

About the Editors

Brian J. Cole, MD, MBA is a Professor in the Department of Orthopedics with a conjoint appointment in the Department of Anatomy and Cell Biology at Rush University Medical Center in Chicago, Illinois. In 2011, he was appointed as Chairman of Surgery at Rush Oak Park Hospital. He is the Section Head of the Cartilage Research and Restoration Center at Rush University Medical Center, a multidisciplinary program specializing in the treatment of arthritis in young, active patients. He also serves as the head of the Orthopedic Master’s Program and trains residents and fellows in sports medicine and research. He lectures nationally and internationally, and through his basic science and clinical research has developed several innovative techniques for the treatment of shoulder, elbow, and knee conditions. He has published more than 1000 articles and has published 11 widely read textbooks in orthopedics.
Dr. Cole was chosen as one of the “Best Doctors in America” each year since 2004 and as a “Top Doctor” in the Chicago metro area each year since 2003. In 2006, he was featured on the cover of Chicago Magazine as “Chicago’s Top Doctor” and was selected NBA Team Physician of the Year in 2009. In 2012, 2013, and 2014, Orthopedics This Week named Dr. Cole as one of the top 19 sports medicine specialists and one of the top 28 North American shoulder surgeons as chosen by his peers. He is the team physician for the Chicago Bulls National Basketball Association team and co-team physician for the Chicago White Sox Major League Baseball team and DePaul University in Chicago.
Joshua D. Harris, MD is an Assistant Professor at Houston Methodist Hospital Department of Orthopedics and Sports Medicine in the Institute of Academic Medicine in Houston, Texas. He holds a conjoint appointment as Assistant Professor of Clinical Orthopedic Surgery at Weill Cornell Medical College in New York, New York. He trains fellows in sports medicine and residents in orthopedic surgery at Houston Methodist Hospital, and medical students from Texas A&M University. He is co-director of the Houston Methodist Cartilage Repair Center and the Houston Methodist Hip Preservation Center.
Dr. Harris received his MD from The Ohio State University in Columbus, Ohio, in 2006. He completed General Surgery internship in 2007 and Orthopedic Surgery residency in 2012, both at The Ohio State University Wexner Medical Center. He completed his Sports Medicine Fellowship at Rush University Medical Center in Chicago, Illinois. Dr. Harris also serves as head team physician for the Houston Dash and the Houston Methodist Endurance Medicine Program and serves as assistant team physician for the Houston Ballet.
     Dr. Harris specializes in knee, hip, and shoulder surgery. His clinical interests include articular cartilage surgery of the knee, hip, and shoulder; meniscoligamentous and realignment surgery of the knee; arthroscopic and endoscopic hip preservation surgery; and open and arthroscopic shoulder surgery. His research interests include clinical, translational, and basic science of knee, hip, and shoulder pathologies and treatments. He has authored and edited more than 150 peer-reviewed publications and book chapters and presented more than 250 national and international presentations. He is a member of several national and international societies, reviews and serves on the editorial board for multiple orthopedic sports medicine journals, and is a member of numerous committees in the American Academy of Orthopaedic Surgeons and other national and regional societies.